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Mapping Cascadian Dynamism

June 30, 2025

It’s hard to label what’s forming across the Pacific Northwest.

These companies don’t fit neatly into a single category. Some are building tactical autonomy, others are advancing compact fusion, modernizing satellite operations, deploying AI-driven robotics, or hardening energy systems. The connective tissue is regional: they’re born out of Cascadia’s unique access to technical talent, physical infrastructure, research depth, and enterprise buyers.

We call this Cascadian Dynamism.

The geography offers structural advantages. Port cities like Seattle and Vancouver provide direct access to logistics, aerospace, and maritime operations. Off-road testing environments are close. The presence of long-range RF labs, defense contractors, space manufacturers, and datacenter operators provides a natural customer base for emerging dual-use and industrial AI startups.

Founders consistently point to the talent layer as the defining factor. Boeing, Amazon, and Microsoft have produced decades of systems engineers, autonomy experts, and cloud infrastructure leads. The Allen Institute for AI, Nvidia’s robotics research, and the University of Washington contribute a steady stream of researchers with deep experience in machine learning, simulation, and computer vision. Fusion and battery chemistry are also heavily concentrated here, with companies like Helion, Zap Energy, Group14, and Sila hiring from a deep regional pool.

Several founders have said, privately and publicly, that this is the only region where their company could be built. It's one of the few places where technical hires understand both AI and physical systems, and where early customers are located within driving distance. The region’s proximity to major datacenter builds, energy utilities, and maritime operations gives startups live environments to test and deploy. Defense buyers and energy procurement teams are actively engaging with startups at earlier stages.

The satellite supply chain is another anchor. Washington produces over half the satellites currently in orbit, thanks to longstanding aerospace manufacturing expertise and a dense network of suppliers. Startups like Starfish, Quindar, and Kymeta are building on that foundation to reimagine in-orbit servicing, control systems, and communications. Robotics startups like Agility are taking advantage of Amazon’s massive warehouse footprint to design and iterate on deployable automation. Other startups are working with research vessels, agricultural testing zones, and off-grid energy projects that would be hard to replicate elsewhere.

Capital is starting to follow the talent. While historically undercapitalized compared to enterprise software, this sector is seeing strong inbound interest. Breakthrough Energy Ventures, Point72, and FUSE are based here. DIU Energy has a foothold in the region. New firms like Conduit and Actuate are being formed around the thesis that complex physical infrastructure is overdue for replatforming —and that Cascadia is one of the few places where that replatforming is already underway.

At Ascend, we have made several investments in this category (four highlighted in the market map), and are on the hunt for more. We call it Frontier AI, or Ai solving the physical world’s hardest problems.

But most of these companies won’t show up in standard SaaS deal flow. Many are operating in stealth, emerging from DARPA projects, research institutes, and spinouts from primes. But the pattern is becoming harder to ignore: engineering-heavy teams, access to buyers, defensible technology, and early federal traction.

There’s a real market taking shape here — one that doesn’t need to chase the latest API trends to build lasting value.

Tags Cascadian Dynamism, Seattle AI Market Map

Startups backed by Ascend are outlined by a bounding box.

Mapping Seattle's Enterprise AI Startups

December 31, 2024

By: Nate Bek

At the start of the year, we spotlighted Seattle’s understated position as one of AI’s most influential hubs.

Since sharing that market map, the scene has evolved dramatically. A wave of AI startup formation and funding has followed breakthroughs in OpenAI’s GPT models and open-source architectures. Researchers, hyperscaler veterans, and serial founders are stepping away from established roles to launch new ventures.

Funding totals, as in other regions, are skewed by major deals. Dave Clark’s Auger ($100M) and Xaira Therapeutics ($1B). But beneath these outliers, a vibrant ecosystem of early-stage startups is thriving, often backed by top-tier investors

Founders are tackling niche infrastructure challenges and building app-based businesses. The city also spawned AI Tinkerers, now a global network connecting thousands of top AI innovators across more than 28 cities.

Seattle remains an enterprise-focused market. This has sharpened our focus on this market map to highlight B2B AI startups, open-source projects, and products, including: AI Stack, Model Development, Business Operations, Vertical Office Apps, and deskless workforce solutions.

Seattle remains the world’s second-most concentrated market for AI and software talent, behind only the Bay Area. The city’s hyperscalers are investing billions in new data centers, advanced chip development, and hiring top-tier AI professionals. At the same time, OpenAI, Anthropic, Nvidia, Meta, and Google have established satellite engineering hubs in the region, further solidifying its position as a global AI powerhouse.

Despite this concentration of talent, Seattle trails other metros in funding totals as access to local capital lags. Our focus remains on deepening our commitment to the region — fostering connections with local talent and supporting the next wave of transformative companies.


Methodology: Our map highlights companies, products, and projects we view as foundational to the broader development of AI, with a focus on enterprise applications, underlying infrastructure, and models. It features more than 120 logos showcasing the wide-ranging potential of AI in real-world settings. Bounding boxes identify companies we’ve invested in, acknowledging any potential bias upfront. This is not a comprehensive list or a ranking — rather, it’s a snapshot of the region’s evolving AI ecosystem.

Tags Ascend, Seattle AI Market Map

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